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KMID : 0370220120560060372
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Yakhak Hoeji
2012 Volume.56 No. 6 p.372 ~ p.376
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Synthesis and Biological Evaluation of Militarin Derivatives
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Che Hai-Yan
Yoon Deok-Hyo
Kim Tae-Woong
Sung Gi-Ho
Park Hae-Il
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Abstract
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Militarin was isolated from Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom and reported to possess anticancer activities against several tumor cells. A number of militarin derivatives bearing different numbers of ethylene glycol unit were synthesized and evaluated for their biological activities related with anticancer and antiinflammatory effects. Among militarin derivatives tested, the compounds 2 and 5 exhibited anticancer and antiinflammatory activities.
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KEYWORD
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militarin derivatives, anticancer activity, antiinflammatory activity, NO, iNOS, COX-2
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